Laboratory Associate/Research Associate, Protein Conjugation  Cleveland, OH 

Objectives:  Associate to assist in peptide/protein modification and bioconjugation

Reports to:  Senior Scientist-Bioconjugation

Responsibilities    

  • Perform peptide/protein modification and bioconjugation to support project goals;
  • Follow developed protocols to perform bioconjugation experiments;
  • Synthesis of peptides using solid-phase Fmoc approaches (manual and automatic);
  • Characterization of peptides using MALDI-MS, LC-MS, HPLC, TLC, UV-Vis, and NMR;
  • Conduct and execute experiments to improve efficiency and scalability;
  • Perform technical procedures in a research laboratory under minimal supervision;
  • Perform tasks in a quick and efficient manner;
  • Collect and record experimental results accurately and meticulously; interpret data, present and document results;
  • Participate in other duties as assigned

Typical activities

  • Perform conjugation reactions using NHS chemistry, carbodiimide chemistry, etc;
  • Set up peptide/protein conjugation reactions, and conduct in-process monitoring using HPLC;
  • Perform scale-up bioconjugation reactions;
  • Prepare reagents such as NHS-activated ester;
  • Generate accurate documentation for experiments;
  • May work with hazardous materials and chemicals;

Skills   

  • Experience and knowledge in organic chemistry;
  • General lab knowledge and operation experience;
  • Experience in purification and analysis of peptides and/or organic compounds using HPLC;
  • Ability to effectively organize and conduct multiple tasks simultaneously, and perform duties in an efficient, fast-paced, and deadline driven work environment;
  • Able to adapt quickly to changing circumstances and project priorities;
  • Interact effectively in a team environment; communicate in a proactive and solution-focused manner;
  • Knowledge and/or experience in peptide/protein chemistry, HPLC, mass spectometry preferred;

Personal characteristics

  • Meticulous and detail oriented, responsible & mature;
  • Passionate, motivated, committed to excellence; driven to make projects and company succeed;
  • Persistent/tenacious, proactive self-starter, thorough follow-up; problem solver;
  • Initiates change. Sense of urgency;
  • Takes responsibility. Gets things done personally as well as through others;
  • Risk taker, flexible and adaptable.  Comfortable with ambiguity;
  • Good with people, team player, sense of humor;
  • Demonstrated strong ethics;

Background  

  • Minimum of 2 years post-graduation experience, preferably in an industry setting;
  • Compensation dependent on skill level and experience;
  • At least 3 distinct, observable examples where achieved meaningful excellence;
  • Must have at least B.S./M.S. in organic chemistry or biochemistry with peptide synthesis experience

Candidates should apply to:

Laboratory Associate/Research Associate, Protein Conjugation

We do not provide sponsorship. Must be eligible to work in the US

Compensation    We offer a competitive salary with bonus based on agreed upon milestones and stock options